{"id":161,"date":"2021-09-11T11:32:26","date_gmt":"2021-09-11T11:32:26","guid":{"rendered":"http:\/\/nurit.local\/?page_id=161"},"modified":"2021-09-11T11:38:06","modified_gmt":"2021-09-11T11:38:06","slug":"field-effect-transistor-biosensors","status":"publish","type":"page","link":"http:\/\/nurit.local\/field-effect-transistor-biosensors\/","title":{"rendered":"Field effect transistor biosensors"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"161\" class=\"elementor elementor-161\" data-elementor-settings=\"[]\">\n\t\t\t\t\t\t\t<div class=\"elementor-section-wrap\">\n\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-35f33103 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"35f33103\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-1e02612d\" data-id=\"1e02612d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6d5cd3ff elementor-widget elementor-widget-image\" data-id=\"6d5cd3ff\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img width=\"150\" height=\"150\" src=\"http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/BGU-LOGO-ROUND-White-150x150.png\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" loading=\"lazy\" srcset=\"http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/BGU-LOGO-ROUND-White-150x150.png 150w, http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/BGU-LOGO-ROUND-White-300x300.png 300w, http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/BGU-LOGO-ROUND-White.png 450w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-28ade627\" data-id=\"28ade627\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7d0c0a8f elementor-widget elementor-widget-heading\" data-id=\"7d0c0a8f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Prof. Nurit Ashkenasy - Research Group<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4ef1ac06 elementor-widget elementor-widget-heading\" data-id=\"4ef1ac06\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Bio-Electronics and Bio-Sensors<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5fc81a2a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5fc81a2a\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-723be741\" data-id=\"723be741\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-676987f4 elementor-widget elementor-widget-image\" data-id=\"676987f4\" data-element_type=\"widget\" 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class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-home menu-item-33\"><a href=\"http:\/\/nurit.local\/\">Home<\/a><\/li>\n<li id=\"menu-item-32\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-32\"><a href=\"http:\/\/nurit.local\/research\/\">Research<\/a><\/li>\n<li id=\"menu-item-31\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-31\"><a href=\"http:\/\/nurit.local\/publications\/\">Publications<\/a><\/li>\n<li id=\"menu-item-30\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-30\"><a href=\"http:\/\/nurit.local\/group\/\">Group<\/a><\/li>\n<li id=\"menu-item-29\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-29\"><a href=\"http:\/\/nurit.local\/positions\/\">Positions<\/a><\/li>\n<li id=\"menu-item-28\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-28\"><a href=\"http:\/\/nurit.local\/news\/\">News<\/a><\/li>\n<li 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data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Field effect transistor biosensors<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7fae2d18 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"7fae2d18\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-17b0e65 elementor-widget elementor-widget-text-editor\" data-id=\"17b0e65\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>The utilization of field-effect transistor (FET) devices in biosensing applications have been extensively studied in the recent years. Qualitative and quantitative understanding of the contribution of the organic layers constructed on the device gate, as well as the electrolyte media, on the behavior of the device is thus crucial. In a publication in <a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/nn100936h?prevSearch=ashkenasy&amp;searchHistoryKey=\"><i>ACS Nano<\/i><\/a> we present an analysis of the contribution of different organic layers on the pH sensitivity, threshold voltage, and gain of a silicon-on-insulator based FET device. We have further monitored how these properties change as function of the electrolyte ionic strength. Our results clearly show that in addition to electrostatic effects, changes in the amphoteric nature of the surface also affect the device threshold voltage. We have thus shown for the first time that apart from the distance of an analyte from the surface, the relative contribution of charge and dipole dictates the detection sensitivity. Furthermore, we have analyzed for the first time the influence of the dielectric properties of the layers on the device gain. A reduction in the gain was found with the successive construction of each layer. These results demonstrate the multilevel influence of organic layers on the behavior of the FET devices.<\/p>\n<p>The detailed understanding of device performance has led us to develop a novel method for affecting the bio-FET recognition signal post analyte binding; providing a tool for signal amplification. To achieve this goal we introduced an excess amount of charge and dipole, using functionalized gold colloids, by a sandwich type secondary antibody binding protocol. This enabled us to manipulate the signal in a selective manner. (See our publication in <a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/elan.201100250\/abstract\"><i>Electroanalysis<\/i><\/a><i>).<\/i><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7c1436e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7c1436e\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-94788e3\" data-id=\"94788e3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d7807cb elementor-widget elementor-widget-image\" data-id=\"d7807cb\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img width=\"437\" height=\"463\" src=\"http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/10.png\" class=\"attachment-medium_large size-medium_large\" alt=\"\" loading=\"lazy\" srcset=\"http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/10.png 437w, http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/10-283x300.png 283w\" sizes=\"(max-width: 437px) 100vw, 437px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">The amplification process.<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-1e05a1e\" data-id=\"1e05a1e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6a97254 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"6a97254\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img width=\"457\" height=\"407\" src=\"http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/11.png\" class=\"attachment-medium_large size-medium_large\" alt=\"\" loading=\"lazy\" srcset=\"http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/11.png 457w, http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/11-300x267.png 300w\" sizes=\"(max-width: 457px) 100vw, 457px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">The amplification factor as function of the back gate voltage.<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-d48fc01 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"d48fc01\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a href=\"http:\/\/nurit.local\/research\/\" class=\"elementor-button-link elementor-button elementor-size-xl\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Back to previous page<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Prof. Nurit Ashkenasy &#8211; Research Group Bio-Electronics and Bio-Sensors Home Research Publications Group Positions News Links Field effect transistor biosensors The utilization of field-effect transistor (FET) devices in biosensing applications have been extensively studied in the recent years. Qualitative and quantitative understanding of the contribution of the organic layers constructed on the device gate, as [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_canvas","meta":[],"_links":{"self":[{"href":"http:\/\/nurit.local\/wp-json\/wp\/v2\/pages\/161"}],"collection":[{"href":"http:\/\/nurit.local\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/nurit.local\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/nurit.local\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/nurit.local\/wp-json\/wp\/v2\/comments?post=161"}],"version-history":[{"count":4,"href":"http:\/\/nurit.local\/wp-json\/wp\/v2\/pages\/161\/revisions"}],"predecessor-version":[{"id":168,"href":"http:\/\/nurit.local\/wp-json\/wp\/v2\/pages\/161\/revisions\/168"}],"wp:attachment":[{"href":"http:\/\/nurit.local\/wp-json\/wp\/v2\/media?parent=161"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}