{"id":154,"date":"2021-09-11T11:28:59","date_gmt":"2021-09-11T11:28:59","guid":{"rendered":"http:\/\/nurit.local\/?page_id=154"},"modified":"2021-09-11T11:31:37","modified_gmt":"2021-09-11T11:31:37","slug":"evaluating-nanopores-structure-function-relations","status":"publish","type":"page","link":"http:\/\/nurit.local\/evaluating-nanopores-structure-function-relations\/","title":{"rendered":"Evaluating nanopores structure-function relations"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"154\" class=\"elementor elementor-154\" data-elementor-settings=\"[]\">\n\t\t\t\t\t\t\t<div class=\"elementor-section-wrap\">\n\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-35f33103 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"35f33103\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-1e02612d\" data-id=\"1e02612d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6d5cd3ff elementor-widget elementor-widget-image\" data-id=\"6d5cd3ff\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img width=\"150\" height=\"150\" src=\"http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/BGU-LOGO-ROUND-White-150x150.png\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" loading=\"lazy\" srcset=\"http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/BGU-LOGO-ROUND-White-150x150.png 150w, http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/BGU-LOGO-ROUND-White-300x300.png 300w, http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/BGU-LOGO-ROUND-White.png 450w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-28ade627\" data-id=\"28ade627\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7d0c0a8f elementor-widget elementor-widget-heading\" data-id=\"7d0c0a8f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Prof. Nurit Ashkenasy - Research Group<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4ef1ac06 elementor-widget elementor-widget-heading\" data-id=\"4ef1ac06\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Bio-Electronics and Bio-Sensors<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5fc81a2a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5fc81a2a\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-723be741\" data-id=\"723be741\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-676987f4 elementor-widget elementor-widget-image\" data-id=\"676987f4\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img width=\"482\" height=\"294\" src=\"http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/image1134.jpg\" class=\"attachment-large size-large\" alt=\"\" loading=\"lazy\" srcset=\"http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/image1134.jpg 482w, http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/image1134-300x183.jpg 300w\" sizes=\"(max-width: 482px) 100vw, 482px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2704c16a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2704c16a\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2fc026d5\" data-id=\"2fc026d5\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-33275cbc eael-simple-menu-hamburger-align-center eael_simple_menu_hamburger_disable_selected_menu_no elementor-widget elementor-widget-eael-simple-menu\" data-id=\"33275cbc\" data-element_type=\"widget\" data-widget_type=\"eael-simple-menu.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div data-indicator-class=\"fas fa-angle-down\" data-dropdown-indicator-class=\"fas fa-angle-down\" class=\"eael-simple-menu-container eael-simple-menu-align-center eael-simple-menu-dropdown-align-left preset-1\"><ul id=\"menu-main\" class=\"eael-simple-menu eael-simple-menu-dropdown-animate-to-top 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elementor-element-2e253bea elementor-widget elementor-widget-heading\" data-id=\"2e253bea\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Evaluating nanopores structure-function relations\n<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7fae2d18 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"7fae2d18\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-17b0e65 elementor-widget elementor-widget-text-editor\" data-id=\"17b0e65\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>In nanopores biosensors, detection is obtained through the change in the ionic current when a molecule translocates through the nanopores (NP), yielding both quantitative and qualitative analytical information. The dependence of the conductance signal on the NP three-dimensional shape, makes it important to decipher the later with high precision. In collaboration with the work of Prof. Kaplan form the Materials Science and Engineering department at the Technion, we performed a detailed study, based on electron microscopy (EM) analysis to accurately extract the NP shape and correlate it with the observed ion conductance. Furthermore, in order to avoid the elaborated EM work required in order to extract the NPs\u2019 shape, we have developed a computational model that enables constructing the NP shape from the dependence of its conductance on the solution ionic strength. This further enables monitoring dynamic changes in the NP shape during sensing experiments. For further details see our publication in <a href=\"http:\/\/apl.aip.org\/resource\/1\/applab\/v97\/i22\/p223105_s1\"><i>APL<\/i><\/a>.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a3e307b elementor-widget elementor-widget-image\" data-id=\"a3e307b\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img width=\"768\" height=\"310\" src=\"http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/8-768x310.png\" class=\"attachment-medium_large size-medium_large\" alt=\"\" loading=\"lazy\" srcset=\"http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/8-768x310.png 768w, http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/8-300x121.png 300w, http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/8-1024x413.png 1024w, http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/8.png 1231w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">On the right we show the cross section of a nanopore drilled by focused electron beam. This cross section was extracted from the top view (left), tilted image (inset) and thickness map (center), all extracted by electron microscopy.<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1ca68e3 elementor-widget elementor-widget-image\" data-id=\"1ca68e3\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img src=\"http:\/\/nurit.local\/wp-content\/uploads\/elementor\/thumbs\/9-pcyenwqcegcfll4oijkdznpi1tv2atpqpb4hpx50yw.png\" title=\"9\" alt=\"Current-voltage of the same pore as function of ionic strength are shown above. Conductance values were extracted from fitting (a). The resulting shape, and its comparison to the shape extracted from the TEM analysis are shown in the inset.\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Current-voltage of the same pore as function of ionic strength are shown above. Conductance values were extracted from fitting (a). The resulting shape, and its comparison to the shape extracted from the TEM analysis are shown in the inset.<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d48fc01 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"d48fc01\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a href=\"http:\/\/nurit.local\/research\/\" class=\"elementor-button-link elementor-button elementor-size-xl\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Back to previous page<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Prof. Nurit Ashkenasy &#8211; Research Group Bio-Electronics and Bio-Sensors Home Research Publications Group Positions News Links Evaluating nanopores structure-function relations In nanopores biosensors, detection is obtained through the change in the ionic current when a molecule translocates through the nanopores (NP), yielding both quantitative and qualitative analytical information. The dependence of the conductance signal on [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_canvas","meta":[],"_links":{"self":[{"href":"http:\/\/nurit.local\/wp-json\/wp\/v2\/pages\/154"}],"collection":[{"href":"http:\/\/nurit.local\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/nurit.local\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/nurit.local\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/nurit.local\/wp-json\/wp\/v2\/comments?post=154"}],"version-history":[{"count":4,"href":"http:\/\/nurit.local\/wp-json\/wp\/v2\/pages\/154\/revisions"}],"predecessor-version":[{"id":160,"href":"http:\/\/nurit.local\/wp-json\/wp\/v2\/pages\/154\/revisions\/160"}],"wp:attachment":[{"href":"http:\/\/nurit.local\/wp-json\/wp\/v2\/media?parent=154"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}