{"id":115,"date":"2021-09-11T11:06:56","date_gmt":"2021-09-11T11:06:56","guid":{"rendered":"http:\/\/nurit.local\/?page_id=115"},"modified":"2021-09-11T11:12:07","modified_gmt":"2021-09-11T11:12:07","slug":"a-helix","status":"publish","type":"page","link":"http:\/\/nurit.local\/a-helix\/","title":{"rendered":"Coiled coil based molecular switches"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"115\" class=\"elementor elementor-115\" data-elementor-settings=\"[]\">\n\t\t\t\t\t\t\t<div class=\"elementor-section-wrap\">\n\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-35f33103 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"35f33103\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-1e02612d\" data-id=\"1e02612d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6d5cd3ff elementor-widget elementor-widget-image\" data-id=\"6d5cd3ff\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img width=\"150\" height=\"150\" src=\"http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/BGU-LOGO-ROUND-White-150x150.png\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" loading=\"lazy\" srcset=\"http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/BGU-LOGO-ROUND-White-150x150.png 150w, http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/BGU-LOGO-ROUND-White-300x300.png 300w, http:\/\/nurit.local\/wp-content\/uploads\/2021\/09\/BGU-LOGO-ROUND-White.png 450w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-28ade627\" data-id=\"28ade627\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7d0c0a8f elementor-widget elementor-widget-heading\" data-id=\"7d0c0a8f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Prof. Nurit Ashkenasy - Research Group<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4ef1ac06 elementor-widget elementor-widget-heading\" data-id=\"4ef1ac06\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Bio-Electronics and Bio-Sensors<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5fc81a2a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5fc81a2a\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-723be741\" data-id=\"723be741\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-676987f4 elementor-widget elementor-widget-image\" data-id=\"676987f4\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div 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data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Coiled coil based molecular switches\n\n<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7fae2d18 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"7fae2d18\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-17b0e65 elementor-widget elementor-widget-text-editor\" data-id=\"17b0e65\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span lang=\"en-US\">We have demonstrated that the unique propensity of proteins to undergo conformational changes, which is widely used in nature for controlling cellular functions, can be used as a mechanism to control the behavior of electronic devices. We have designed and prepared new dimeric coiled coil proteins that adopt different conformations due to parallel or anti-parallel relative orientations of their\u00a0<\/span><span lang=\"en-US\">a<\/span><span lang=\"en-US\">-helix peptide monomers. In a recent publication in\u00a0<\/span><a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/ja907902h?prevSearch=ashkenasy&amp;searchHistoryKey\"><span lang=\"en-US\">JACS<\/span><\/a><span lang=\"en-US\">\u00a0we have shown for the first time that by controlling the conformation of these proteins, attached as monolayers to gold, a quantitative modulation of the gold electrode work function (W<\/span><span lang=\"en-US\"><sub>F<\/sub><\/span><span lang=\"en-US\">) is achieved. Furthermore, charge transport through the proteins as molecular bridges was found to be controlled by the different protein conformations, producing either rectifying or Ohmic-like behavior.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a3e307b elementor-widget elementor-widget-image\" data-id=\"a3e307b\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img src=\"http:\/\/nurit.local\/wp-content\/uploads\/elementor\/thumbs\/1-pcydopnunzxk2fzpeqj5v3okkvo89j8fwycphy0ys4.png\" title=\"1\" alt=\"The I-V curves of the parallel and anti-parallel coiled coil proteins show switching between rectifying and Ohmic-like behavior. The work function (in the inset) shows an increase in the work function due to the elimination of the polar PC groups from the surface.\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">The I-V curves of the parallel and anti-parallel coiled coil proteins show switching between rectifying and Ohmic-like behavior. The work function (in the inset) shows an increase in the work function due to the elimination of the polar PC groups from the surface. \n<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b7f6be5 elementor-widget elementor-widget-text-editor\" data-id=\"b7f6be5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>The implementation of such proteins in device applications, in particular for solar energy conversion applications, will be obtained by the targeted engineering of proteins that will be functionalized specifically in order to perform the desired function and will be equipped with other units that will ensure their stable assembly in the desired device configuration.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d48fc01 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"d48fc01\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a href=\"http:\/\/nurit.local\/research\/\" class=\"elementor-button-link elementor-button elementor-size-xl\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Back to previous page<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Coiled coil based molecular switches Prof. Nurit Ashkenasy &#8211; Research Group Bio-Electronics and Bio-Sensors Home Research Publications Group Positions News Links Coiled coil based molecular switches We have demonstrated that the unique propensity of proteins to undergo conformational changes, which is widely used in nature for controlling cellular functions, can be used as a mechanism [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_canvas","meta":[],"_links":{"self":[{"href":"http:\/\/nurit.local\/wp-json\/wp\/v2\/pages\/115"}],"collection":[{"href":"http:\/\/nurit.local\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/nurit.local\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/nurit.local\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/nurit.local\/wp-json\/wp\/v2\/comments?post=115"}],"version-history":[{"count":14,"href":"http:\/\/nurit.local\/wp-json\/wp\/v2\/pages\/115\/revisions"}],"predecessor-version":[{"id":130,"href":"http:\/\/nurit.local\/wp-json\/wp\/v2\/pages\/115\/revisions\/130"}],"wp:attachment":[{"href":"http:\/\/nurit.local\/wp-json\/wp\/v2\/media?parent=115"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}