The
Nature of the Hole Interactions
Halogen bonding is the new
player in the world of non-covalent
interactions. In the 21st century similar
systems are continuously being discovered,
including chalcogen, pnictogen, tetrel,
beryllium, or aerogen bonds, that can come as
σ-holes, π-holes, or even δ-holes. The bonding
pattern includes an electrostatic hole (a
positive region in the electrostatic
potential) and the possibility of bonding by
charge transfer. We are developing a model
that explains the reasons why these two types
of interactions always come hand-in-hand both
in directionality and strength, and elucidates
on the agonistic effect between the different
interactions.
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